Study: The effects of marijuana smoking on lung function in older individuals

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Abstract

Background Preceding research have linked marijuana exposure with elevated respiratory symptoms and chronic bronchitis amongst lengthy-term cannabis smokers.The lengthy-term effects of smoked marijuana on lung function stay unclear.

Techniques We determined the association of marijuana smoking with the danger of spirometrically-defined COPD [post-bronchodilator FEV1/FVC<0·7] in 5291 population-primarily based men and women and the price of decline in FEV1 in a subset of 1285 males and ladies, aged 40 years and older, who self-reported use (or nonuse) of marijuana and tobacco cigarettes and performed spirometry prior to and just after inhaled bronchodilator on a number of occasions. Evaluation for the decline in FEV1 was performed employing random mixed effects regression models adjusted for age, gender, and physique mass index. Heavy tobacco smoking and marijunana smoking was defined as &gt20 pack-years and &gt20 joint-years, respectively.

Benefits About 20% of participants had been or have been present marijuana smokers with most also getting smoked tobacco cigarettes (83%). Amongst heavy marijuana customers, the danger of COPD was considerably elevated (adjusted odds ratio, aOR, two.45 95% CI, 1.55–3.88). Compared to under no circumstances-smokers of marijuana and tobacco, heavy marijuana smokers and heavy tobacco smokers knowledgeable a more quickly decline in FEV1 by 29·5 mL·year−1 (p=0·0007) and 21·1 mL·year−1 (p&lt0.0001), respectively.These who smoked each knowledgeable a decline of 32.31 mL·year−1 (p&lt.0001).

Interpretation Heavry marijuana smoking increases the danger of COPD and accelerates FEV1 decline in concomitant tobacco smokers beyond that observed with tobacco alone.

Footnotes

This manuscript has lately been accepted for publication in the European Respiratory Journal. It is published right here in its accepted kind prior to copyediting and typesetting by our production group. Following these production processes are full and the authors have authorized the resulting proofs, the write-up will move to the most current concern of the ERJ on-line. Please open or download the PDF to view this write-up.

Conflict of interest: Dr. Tan reports grants from Canadian Institute of Heath Investigation (CIHR/Rx&ampD Collaborative Investigation Plan Operating Grants- 93326) with sector partners Astra Zeneca Canada Ltd., Boehringer-Ingelheim Canada Ltd, GlaxoSmithKline Canada Ltd, Merck, Novartis Pharma Canada Inc., Nycomed Canada Inc., Pfizer Canada Ltd., through the conduct of the study.

Conflict of interest: Dr. Bourbeau reports grants from Canadian Institute of Heath Investigation (CIHR/Rx&ampD Collaborative Investigation Plan Operating Grants- 93326) with sector partners Astra Zeneca Canada Ltd., Boehringer-Ingelheim Canada Ltd, GlaxoSmithKline Canada Ltd, Merck, Novartis Pharma Canada Inc., Nycomed Canada Inc., Pfizer Canada Ltd., through the conduct of the study.

Conflict of interest: Dr. Aaron has practically nothing to disclose.

Conflict of interest: Dr. Hogg has practically nothing to disclose.

Conflict of interest: Dr. Maltais has practically nothing to disclose.

Conflict of interest: Dr. Hernandez reports grants from Canadian Institute Wellness Investigation, through the conduct of the study grants and individual charges from AstraZeneca, grants and individual charges from Boehringer Ingelheim, grants and individual charges from GlaxoSmithKline, individual charges from Merck, grants and individual charges from Novartis, grants and individual charges from Takeda, individual charges from Grifols, grants from CSL Behring, individual charges from Pfizer, individual charges from Almirall, outdoors the submitted operate.

Conflict of interest: Dr. Marciniuk has practically nothing to disclose.

Conflict of interest: Dr. Chapman reports grants from Novartis, grants from Almirall, grants from Boehringer Ingelheim, grants from Forest, grants from GSK, grants from AstraZeneca, grants from Amgen, grants from Roche, grants from CSL Behring, grants from Grifols, grants from Genentech, grants from Kamada, through the conduct of the study other from CIHR-GSK Investigation Chair in Respiratory Wellness Care Delivery, outdoors the submitted operate.

Conflict of interest: Dr. To has practically nothing to disclose.

Conflict of interest: Dr. FitzGerald has practically nothing to disclose.

Conflict of interest: Dr. Walker reports grants from Canadian Institute of Wellness Investigation, grants from AstraZeneca Canada Ltd, grants from Boehringer Ingelheim Canada, grants from GlaxoSmithKline Canada, grants from Novartis, through the conduct of the study grants from Respiratory Wellness Strategic Clinical Network Alberta, individual charges from AtraZeneca, individual charges from GlaxoSmithKline, individual charges from Novartis, outdoors the submitted operate.

Conflict of interest: Dr. Road has practically nothing to disclose.

Conflict of interest: Dr. Zheng has practically nothing to disclose.

Conflict of interest: Dr. Zhou has practically nothing to disclose.

Conflict of interest: Dr. Yau has practically nothing to disclose.

Conflict of interest: Dr. Benedetti has practically nothing to disclose.

Conflict of interest: Dr. O’donnell has practically nothing to disclose.

Conflict of interest: Dr. Sin reports grants from AstraZeneca, through the conduct of the study grants from Merck, individual charges from Sanofi-Aventis, individual charges from Regeneron, grants and individual charges from Boehringer Ingelheim, grants and individual charges from AstraZeneca, individual charges from Novartis, outdoors the submitted operate.

Complete Study At  https://erj.ersjournals.com/content material/early/2019/09/11/13993003.00826-2019

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